Endocrine Abstracts

Background and Aims: As a loss of functional β-cell mass contributes to type 2 diabetes (T2D), increasing β-cell proliferation is a potential therapy to compensate for impaired insulin output. Long non-coding RNAs (lncRNAs) regulate several key β-cell genes and the presence of more than 1100 human β-cell enriched lncRNAs raises the potential for wider roles. Here we have identified 5 independent studies that capture the β-cell transcriptome during adap...

The success of islet transplantation in the treatment of type 1 diabetes has been limited by the progressive decline in islet function and viability during isolation and post transplantation. The aims of the current study were to investigate the capacity of a multifunctional progenitor cell type, mesenchymal stromal cells (MSCs), to improve islet insulin secretory function and viability after exposure to transplantation relevant stressors. Mouse islets were cultured with low (...